Immunologic injury in measles virus infection. II. Suppression of immune injury through antigenic modulation

Immature CD4+CD8+ Thymocytes Are Preferentially Infected by Measles Virus in Human Thymic Organ Cultures

Cells of the human immune system are important target cells for measles virus (MeV) infection and infection of these cells may contribute to the immunologic abnormalities and immune suppression that characterize measles. The thymus is the site for production of naïve T lymphocytes and is infected during measles. To determine which populations of thymocytes are susceptible to MeV infection and w...

Natural measles causes prolonged suppression of interleukin-12 production.

Among vaccine-preventable diseases, measles is the preeminent killer of children worldwide. Infection with measles virus (MV) is associated with prolonged suppression of cell-mediated immune responses, a phenomenon that is thought to underlie the susceptibility to secondary infections that accounts for most measles-related mortality. Interleukin (IL)-12 is critical for the orchestration of cell...

Modulation of immune system function by measles virus infection: role of soluble factor and direct infection.

Measles virus infection can result in a variety of immunologic defects. We have begun studies to determine the basis for the lack of immune responsiveness to antigen and mitogen following infection. Here we present data showing that Epstein-Barr virus-transformed B-cell lines infected with measles virus produce a soluble factor that can inhibit antigen-specific T-cell proliferation and inhibit ...

تعدیل پاسخ ایمنی سلولی متعاقب سوختگی در مدل حیوانی موش Balb/c

Background: Infection is the major cause of death in thermal injury patients. Severe suppression of the immune system is the major cause of infection following burn injury. The aim of this study was to modulate the cell-mediated immune response by the use of cimetidine and pyrimethamine in an animal burn model. Materials and Methods: Male Balb/c mice were anesthetized, and given a 10% total ...

Studies in Borreliae II. Some Immunologic, Biochemical and Physical Properties of the Antigenic Components of Borrelia turicatae